BackgroundRAF kinases direct ERK MAPK signaling to distinct subcellular compartments in response to growth factor stimulation.Methodology/principal findingsOf the three mammalian isoforms A-RAF is special in that Home Coffee Machines one of its two lipid binding domains mediates a unique pattern of membrane localization.Specific membrane binding is
In homeostatic scaling at central MISC synapses, the depth and breadth of cellular mechanisms that detect the offset from the set-point, detect the duration of the offset and implement a cellular response are not well understood.To understand the time-dependent scaling dynamics we treated cultured rat hippocampal cells with either TTX or bicucculli
Abstract At a time of unpredictable challenges for health, one trend is certain: there is an exceedingly high demand for functional implants, particularly bone grafts.This has encouraged the emergence of bone tissue engineering substitutes as an alternative method to conventional bone grafts.However, the current approaches in the field face several
Abstract At a time of unpredictable challenges for health, one trend is certain: there is an exceedingly high demand for functional implants, particularly bone grafts.This has encouraged the emergence of bone tissue engineering substitutes as an alternative method to conventional bone grafts.However, the current approaches in the field face several